SIngle Molecule Spectroscopy of Amino Acides and Peptides by Recognition Tunneling

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Venue:AHC4, Rm101, MMC

Abstract

Single molecule protein sequencing is a critical enabling technology in the quest for disease-related biomarkers. Accurately identifying individual amino acid molecules is a significant step towards this goal. Recognition Tunneling (RT) can be used to identify naturally occurring amino acids, including enantiomers, modified amino acids, isobaric isomers and short peptides. The RT electronic "fingerprints" of amino acid molecules can be characterized, and subsequently automatically identified, with a machine-learning algorithm.

Biography

Stuart Linday, Ph.D., Specializes in biophysics at the molecular level and scanning probe microscopy. Much of his work is aimed at speedier diagnosis and an understanding of the molecular basis of disease. He holds 29 US patents and is a technology advisor for the Atomic Force Microscope Division of Agilent Technologies. Agilent has acquired Molecular Imaging Corporation, which he co-founded in 1993. Dr. Lindsay is the author of the first comprehensive text for nanoscience, "Introduction to Nanoscience" (OUP, 2009). He is a fellow of the American Association for the Advancement of Science and the American Physical Society.