AFM force measurements of ligand-receptor interaction
My laboratory is interested in understanding how weak intermolecular forces generated by the interactions of biomolecules contribute to cellular functions. Our experimental approach involves the acquisition of direct measurements of intramolecular and intermolecular forces at the level of individual molecules. Thus, an important component of my research is the development of advanced biophysical techniques with the sensitivity and precision to investigate the submicroscopic properties of biological systems under near physiological conditions. One such technique employs the atomic force microscope (AFM) to measure the mechanical forces generated during cell adhesion and migration. This talk will summarize advances in AFM force measurements of ligand-receptor interaction for single molecule and cell adhesion studies.
r. Vincent T. Moy is currently a professor in the Department of Physiology & Biophysics at University of Miami medical school. He is interested in understanding how weak intermolecular forces generated by the interactions of biomolecules contribute to cellular functions. He received his B.A. in biophysics/Math from University of Pennsylvania in 1984, and his Ph.D. in chemical physics from Stanford University in 1988. He received postdoc training in Biochemistry at the University of UC San Diego from 1988 to1993. Before joining University of Miami in 1995 as an assistant professor, he worked as an assistant in Physics at Technical University Munich at Germany.