Gradients of Transmembrane Voltage Potential Across Tissues Control Anatomy
Tufts University’s Center for Regenerative and Developmental Biology (TCRDB) integrates molecular physiology, cell biology, developmental genetics, biophysics, computer science, and engineering to understand the storage and processing of information in living tissues. The research focuses on the study of bioelectrical signals that make up part of the language used by cells to fulfill complex patterning and organizational needs of the host organism. These natural voltage gradients exist in all cells and we use a convergence of variety of genetic, biophysical and molecular physiology to develop new tools to track and manipulate these bioelectric conversations between cells and tissues. This knowledge will help us in understanding how to apply this bioelectric information processing modality in regenerating such organ systems for treatment of birth defects, injuries and diseases.
Dr. Vaibhav Pai obtained his B.S. in Microbiology from University of Mumbai (Bombay), India in 2001; M.S. in Biophysics from University of Mumbai (Bombay), India in 2003; Ph.D. in Systems Biology and Physiology from University of Cincinnati, Ohio in 2009. Currently, he is working as a Research Associate at Tufts University’s Center for Regenerative and Developmental Biology (TCRDB) under the leadership of Dr. Michael Levin.