A Time-traveller’s Guide to Protein Space

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Venue:AHC3-205, MMC

Abstract:

Proteins are flexible in structure and function. Conformationally flexible regions are found to different extent in most proteins, ranging from fully structurally disorder proteins to proteins with almost no conformational flexibility. Embedded in these regions are post-translational modification sites and numerous functional motifs that commonly act as on/off switches of various biomolecular interactions and functions, in response to external and internal stimuli. Aiming to elucidate how these regions evolve, we are studying the evolutionary dynamics of various structural and functional properties in these intricate regions. This talk will focus on protein evolution and in particular some of our previous work on a comparative whole genome approach studying flaviviruses, our current large-scale endeavors in Metazoa, and future perspectives.

Biography:

Dr. Siltberg-Liberles obtained her M.S. degree in 2003 from Stockholm Bioinformatics Center, Stockholm University, Sweden. In 2008, Dr. Siltberg-Liberles attained her Ph.D. degree from the Department of Biomedicine at University of Bergen, Norway. Her Ph.D. thesis focused on evolution of protein structure and function with an emphasis on regulation. After a short postdoc in protein engineering, Dr. Siltberg-Liberles was the director of the Bioinformatics Service Core at University of Wyoming until Aug 2013 when she started her current position as an Assistant Professor in Biological Sciences at FIU.

The event is free and open to the public. Undergraduates and graduates are encouraged to attend!

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